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KMID : 1007520150240020673
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Food Science and Biotechnology
2015 Volume.24 No. 2 p.673 ~ p.679
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Antioxidant Properties of Elaeagnus umbellata Berry Solvent Extracts against Lipid Peroxidation in Mice Brain and Liver Tissues
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Saira Ishaq
Habib Ahmad Rathore
Syed Mubashar Sabir
Muhammad Saeed Maroof
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Abstract
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Elaeagnus umbellata is a plant that grows in the hilly areas of Pakistan. Free radical scavenging activities and anti-lipid peroxidative properties of hot water, methanol, n-hexane, and acetone extracts of E. umbellata berries were evaluated. Extracts showed inhibition against thiobarbituric acid reactive species (TBARS) induced using the pro-oxidants iron (10 μM FeSO4) and sodium nitroprusside (5 μM) in brain and liver homogenates of mice. Extracts also showed metal chelating activities of IC50 (extract concentration that causes 50% scavenging)=40-43 μg/mL and DPPH radical scavenging activities of IC50=45.4- 49 μg/mL. HPLC analysis revealed the presence of gallic, vanillic, coumaric, ferulic, sinapic, and caffeic acids in berries. The fruit of E. umbellata is a potential source of antioxidants with therapeutic importance.
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KEYWORD
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Elaeagnus umbellate, lipid peroxidation, DPPH radical scavenging activity, pro-oxidant, iron chelation
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